Research Progress in Single-Cell Omics of Human Endometrium
JIANG Le-ran
ZHANG Yuan
WANG Lin
DIAO Fei-yang
Abstract：The expression and function of various subtypes of cells in the endometrium are crucial for maintaining normal endometrial function and providing an environment for embryo implantation.In recent years,the single-cell omics has gradually become an important tool for the basic research and clinical application related to endometrium,as it can perform the high-throughput sequencing of endometrium from different sources and stages at the single-cell level.This article provides a systematic review of existing studies on the single-cell omics related to the endometrium,including the physiological status of the endometrium,as well as the single-cell differences and intercellular interactions in pathological conditions such as recurrent spontaneous abortion,endometriosis,adenomyosis,thin endometrium,intrauterine adhesions,repeated implantation failures and endometrial cancer.The deeper understanding of the application of single-cell omics of endometrium is helpful for us to reveal the pathophysiological mechanisms of the endometrium-related diseases.
Keywords：EndometriumSingle-cell analysisHigh-throughput nucleotide sequencingReceptivityEmbryo implantation
Publication Date：2024-05-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 216-221 )