Application Progress of Progestin-Primed Ovarian Stimulation
LI Cai-hua
GUO Pei-pei
JIANG Xiao-hua
FANG You-yan
ZHOU Ping
WEI Zhao-lian
Abstract：In assisted reproductive technology,it is very important to prevent the premature endogenous luteinizing hormone(LH)peak in process of controlled ovarian stimulation.Traditional controlled ovarian stimulation protocols with gonadotropin-releasing hormone(GnRH)analogues(GnRH agonists or antagonists)to inhibit the level of endogenous LH have many disadvantages such as high cost and inconvenient use.Progestin-primed ovarian stimulation(PPOS)protocol has been proved to achieve good clinical outcomes in various populations by the negative feedback effect of exogenous progesterone on pituitary gland to inhibit LH level,and its offspring safety has also been preliminarily confirmed.In this paper,the mechanism of PPOS,application of different exogenous progesterone drugs,application effects of different populations and offspring safety of PPOS were reviewed.
Keywords：Ovulation inductionReproductive techniquesassistedLuteinizing hormonePregnancy outcomePremature LH surgeProgestin-primed ovarian stimulation
Publication Date：2024-01-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 68-73 )