Research Progress on Post-Translational Modification in Polycystic Ovary Syndrome
LIU Yi-ran
FENG Rui-zhi
QIAN Yun
Abstract：Polycystic ovary syndrome(PCOS)is one of the most common endocrine disorders in women,but its pathogenesis is unknown.Current researches suggested that the disease may be influenced by a variety of factors,including epigenetic and environmental factors.In recent years,the incidence of PCOS has been increasing,leading to a decline in the quality of life of patients.Therefore,it is necessary to actively explore new treatments.Post-translational modification(PTM)is an important way to regulate protein function.Most studies have found that phosphorylation is closely related to insulin resistance of PCOS,acetylation is mainly focused on the quality of PCOS oocytes,and methylation is closely related to PCOS lipid metabolism.Exploring the role of PTM in the occurrence and development of PCOS may provide new ideas for targeted treatment of this disease.
Keywords：Polycystic ovary syndromeProtein processingpost-translationalPhosphorylationAcetylationMethylationUbiquitination
Publication Date：2024-01-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 38-42 )