Pathways of Insulin Resistance in Ovarian Granulosa Cells of Polycystic Ovary Syndrome Patients
REN Lu-lu
REN Wen-chao
ZHANG Xiao-xuan
REN Chun-e
Abstract：Insulin resistance(IR)is associated with the genesis and development of polycystic ovary syndrome(PCOS).The abnormity of insulin-related signaling pathways causes metabolism disorder,which affects follicle development and quality.In ovarian granulosa cells of PCOS,the classical pathways of insulin include phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)and mitogen-activated protein kinase(MAPK)/extracellular signal-regulated kinase(ERK).The pathways related with inflammation include Toll-like receptor(TLR)/nuclear factor-κB(NF-κB),and the pathways of oxidative stress include nuclear factor-erythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)and GTPase of immunity-associated protein 7(GIMAP7)/sonic hedgehog(SHH).There are multiple pathways related with metabolism,such as the lipid metabolism-related pathway of activating transcription factor 4(ATF4).Therefore,clarifying the IR-related signal transduction pathway and molecular mechanism in ovarian granulosa cells of PCOS patients can supplement the knowledge of PCOS pathogenesis,and further provide new ideas for the treatment of PCOS.
Keywords：Polycystic ovary syndromeInsulin resistanceIntracellular signaling peptides and proteinsSignal transductionGranulosa cells
Publication Date：2024-01-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 32-37 )