Detection of Antinuclear Antibody, Anticardiolipin Antibody and Anti-β2 Glycoprotein 1 Antibody in Patients with Moderate or Severe Endometriosis
ZHANG Yuan
JIANG Chun-yan
WU Wei
MA Xiang
HUANG Jie
MAO Yun-dong
LIU Jia-yin
SHU Li
Abstract：Objective: To evaluate the detections of antinuclear antibody (ANA), anticardiolipin antibody (AGL) and anti-β2 glycoprotein 1 antibody (aβ2Gp1) in patients with moderate and severe endometriosis before IVF/IGSI treatment. Methods：From January 2018 to April 2019, 86 patients with moderate and severe endometriosis (EMs group, 86 cases) and 82 women who were planned to undertake IVF/IGSI treatment due to male factors (control group, 82 cases) were collected as the subjects. The level of serum ANA was detected by immunofluorescence, and the levels of AGL and aβ2=GPl antibodies were detected by enzyme –linked immunosorbent assay. Results：The total positive rate of at least one antibody positive in the EMs group was 31.40% (27/86), while that in the control group was 12.19% (10/82). The difference between the two groups was statistically significant (P＜0.05); The total positive rate of ANA in the EMs group [5.81% (5/86) ] was slightly higher than that in the control group[1.22% (1/82), but P＜0.05]. The total positive rate of AGL in the EMs group [13.95% (12/86)] was also slightly higher than that in the control group [6.10% (5/82), but P>0.05].Interestingly, the total positive rate of aβ2GPl in the Ems group [6.28%(14/86)]was significantly higher than that in the ontrol group[6.10% (5/82), P＜0.05] Conclusions:The combined screening of serum ANA, AGL and aβ2GP1 is recommended for patients with moderate and severe endometriosis before IVF/IGSI treatment. The positive rate of aβ2GP1 in patients with moderate and severe endometriosis is high, which deserves clinical attention.
Keywords：AntibodiesantinuclearAnti-nuclear antibodyanticardiolipinantiphospholipidAnti-β2-glycoprotein 1 antibodyEndomeh-iosisEnzyme-linked immunosorbent assayFluoroimmunoassay
Publication Date：2020-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 97-100 )