Molecular Epidemiological Characteristics of HPV Infection and the Relationship with Cervical Lesion in Chengdu China

LUO Zhong-qiu; LENG Ping; LIU Xiang-qin; LUO Ping

doi:10.3969/j.issn.1674-1889.2018.01.011

Abstract：Objective:To study the molecular epidemiological characteristics of cervical human papillomavirus (HPV) infection and the relationship with cervical precancerous lesion among women in Chengdu China.Methods:A total of 8 204 patients who tested HPV infection during January 2015 to January 2017 were enrolled.All patients had the HPV genotyping detection,among them 4 390 patients were requested the cervical cytology test and 229 patients had pathological diagnosis.Results:In 8 204 cases,the HPV infection rate was 23.28％,including 58.53％ of high-risk HPV infection.Most of HPV infections were single infection (72.88％),mainly caused by HPV52,HPV58 and HPV16,while in those multiple HPV infections the double infections took priority of 62.13％,mainly caused by HPV52 combined with HPV58,HPV16 and HPV53.There was significant difference in the HPV infection rate of different age groups (P＜0.001),and this rate in the ≤20 age group was highest (61.76％).The increasing rate of high-risk HPV infection was along with the diagnosis grade of cytology,and this rate in people with cytological abnormality was significantly higher than that in normal people(P=0.025).The high-risk HPV infection was related to the different grade of CIN and cervical cancer,however the low-risk HPV infection was only correlated with CIN I.Conclusions:The distribution of HPV genotypes has significant difference in the different age group and region,while the HPV infection rate is positively related with cervical lesions.This study can provide more reasonable reference for the development of specific HPV vaccine that suit for the women in Chengdu,and for the screening of cervical lesions and the prevention of cervical cancer.