Effects of MicroRNAs on Early Embryonic Development and Implantation
XU Dan
WANG Yu-xia
YANG Hai-ting
PAN Cui-jiao
Abstract：MicroRNAs (miRNAs) play a regulatory role in early embryonic development and implantation. Abnormal expression of miRNAs may result inabnormal embryonic development and implantation failure by inducing the excessive apoptosis of trophoblasts, abnormal placental angiogenesis, inhibition of endometrial decidualization and maternal-fetal interface immune response. Moreover, the polymorphism of miRNAs leads to the embryo loss by inhibiting the proliferation of trophoblast cells and promoting apoptosis. In this article, the influence of miRNAs on early embryonic development and implantation was reviewed.
Keywords：MicroRNAsEmbryonic developmentEmbryo implantationTrophoblast cell
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 498-502 )