Expressions of AhR and CYP1A1 Protein in Chorionic and Decidual Tissues of Unexplained Embryonic Diapauses and Its Significance
WANG Yun-feng
LIAN Li-fen
HOU Hai-yan
LIANG Jing
CHEN Jun
CHEN Ya-qiong
DONG Qu-long
Abstract：Objective:To test the expressions of aryl hydrocarbon receptor (AhR) and cytochrome P4501A1 (CYP1A1) protein in the chorionic and decidual tissues of embryonic diapause. Methods:30 cases of early unexplained embryonic diapauses (the study group) and 30 cases of induced abortion in normal early pregnancy (the control group) were selected. The expression levels of AhR and CYP1A1 in the chorionic tissues and decidual tissues were detected by immunohistochemical method. Results:The study group had significantly high expression of AhR protein in the chorionic tissues (0.58±0.03, P<0.01) and the decidual tissues (0.56±0.03, P<0 . 01 ) when compared with the control group ( 0 . 25 ± 0 . 04 , 0 . 26 ± 0 . 04 ) . Meanwhile , the study group had significantly high expression of CYP1A1 protein in the chorionic tissues (0.60 ±0.01, P<0.01) and the decidual tissues (0.57±0.01, P<0.01) when compared with the control group (0.22±0.03, 0.24±0.03). Conclusions:The increased expressions of AhR and CYP1A1 protein in the chorionic and decidual tissues may be related to the pathogenesis of embryonic diapauses.
Keywords：Embryo lossDeciduaChorionHydrocarbonsaromaticCytochrome P-450 CYP1A1Embryonic diapauses
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 451-453,473 )