Association between Assisted Reproductive Technology and Disorders of Imprinted Genes
JIA Qing-ge
Abstract：Assisted reporductive technology (ART) is an effective treatment of infertility.However,the safety of reproductive genetics of ART has being concerned.It was reported that the adverse pregnancy outcomes of ART such as low birth weight,spontaneous abortion,fetal malformation,premature delivery,perinatal death were increased.A large number of studies showed that some non-physical interventions on infertility patients,such as the controlling ovarian hyperstimulation,in vitro fertilization and embryo operation,could affect the epigenetics.The imprinting gene play a important role in fetal development during epigenetic modification.ART manipulation is just in the process of epigenetic reprogramming.Therefore,the disorders of imprinting gene will not only impact the fetal development,but also induce developmental abnormalities and many related diseases after birth.This review summarizes the relationship between ART and the disorders of imprinting genes such as BeckwithWiedemann syndrome,Prader-Willi syndrome,Angelman syndrome,Silver-Russell syndrome and so on.
Keywords：Reproductive techniquesassistedGenomic imprintingBeckwith-Wiedemann syndromeDNA methylationSequence analysisDNAAcetylation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 404-407 )