Sirt3 and Its Effect in ROS-mediated Reproductive Diseases
HUANG Qiao-yao
Abstract：Sirt3,a member of the sirtuin family of type Ⅲ histone deacetylases (HDACs) dependented on nicotinamide adenine dinucleotide (NAD+),was located in the mitochondrial matrix of mammalian cells.By deacetylating the most of mitochondrial proteins,sirt3 plays an important role in mitochondria.The deacetylation by sirt3 affects the quantity of reactive oxygen species (ROS),from transcription factors to metabolic enzymes,such as hypoxia-inducible factor (HIF-1),p53,peroxisome proliferator-activated receptor γcoactivator 1et (PGC-1α) and other factors;antioxidant enzymes catalase (CAT),amino acid dehydrogenase (GDH),catalase and superoxide dismutase 1 (SOD1) and other metabolic enzymes.Just based on above mechanism,sirt3 participates in the pathogenesis or pathophysiology of the decreased potential of embryonic development,premature ovarian failure,ovarian tumor and other reproductive diseases.This review summarizes the biological characteristics of sirt3,the molecular mechanism of sirt3 in regulatiog ROS,and the effect of sirt3 in the ROS-mediated reproductive diseases.
Keywords：Sirt3Reactive oxygen speciesFemale urogenital diseases
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 318-322 )