Application Progress of Embryonic Stem Cell and Induced Pluripotent Stem Cell in Embryonic Toxicity Test
LU Di
ZHANG Wei
Abstract：The effects of chemicals or drugs on germ cells or early embryos may lead to infertility or the impaired development of pre-implantation embryos.Studies showed that this impaired development could result in embryotoxic or teratogenic effects.The reliable data on the potential toxic effect on human embryos is necessary for any new drug before its clinical application.Embryonic stem cell (ESC) is widely used as a cell model in the embryotoxic study due to its unique capacities of serf-renewal and differentiation.The embryonic stem cell test (EST) is an in vitro alternative method to evaluate embryotoxicity,which have obtained international recognition.However,EST has its limitations in speedability and sensitivity.The induced pluripotent stem cells (iPSC) with characteristics of proliferation and differentiation,similar to ESC,has gradually been used in the embryonic toxicity test.
Keywords：Multipotent stem cellsEmbryonic stem cellsInduced pluripotent stem cellsEmbryo toxicity
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 130-136 )