Change of Sperm Flagellar Protein during Epididymal Maturation
YE Lu-yao
JING Ran
Abstract：Sperm functional maturation refers to the gradual capacitation of flagellar motility and fertilization during epididymal transition.Recently,with the development and application of cutting-edge techniques of gene function study such as gene knockout and gene over-expression,the pivotal role of the flagellar protein involved in structure changes and modification during sperm maturation have been revealed.For instance,glyceraldehyde 3-phosphate dehydrogenase (GAPDH) significantly increases,and binds to fibrous sheath during epididymal transition,which is involved in glycolysis and energy production.A kinase anchoring protein 4 (AKAP4),a protein associated with flagellar motility,undergoes phosphorylation in epididymis.Herein,we review the changes of flagellar proteins in quantity,structure and function in order to elucidate the physiological and pathological mechanisms of sperm motility and clinical asthenozoospermia,and to provide a reference for the development of male contraceptive vaccine.
Keywords：SpermatozoaSperm maturationEpididymisFlagellin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 120-124 )