Application of Fetal Chromosomal Examination in Recurrent Miscarriages
ZHONG Yun
OU Jian
LI Hong
Abstract：Fetal chromosomal aneuploidy is one of the most common causes of spontaneous abortion. However, the incidence of fetal chromosomal abnormalities in those couples with the recurrent pregnancy loss (RPL) is negatively related to the number of their miscarriages. There is a query on the application of routine karyotype testing in RPL. By reviewing the incidence of fetal chromosomal abnormalities and pathogenesis of RPL, and the advancements in genetic testing of abortion products, the clinical application of genetic testing in diagnosis and treatment of RPL was evaluated. It was recommended that RPL couples get a specialist′s genetic consult, and that the chromosome testing of abortions form RPL couples, the next-generation sequencing technologies if possible, be asked. With the progress of embryo-fetal genetic testing, the pregnancy outcomes of RPL will be significantly improved in the future.
Keywords：AbortionhabitualChromosome disordersKaryotypingPregnancy outcomeAneuploidy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 61-65 )