Effects of Adipocytokines on the Pathogenesis of Early Spontaneous Abortion
ZHANG Xiao-ya
WANG Yu-xia
YANG Hai-ting
Abstract：Adipocytokines, such as adiponectin, leptin, tumor necrosis factor-α (TNF-α), visfatin and interleukins (ILs), can affect embryo implantation, intrauterine environment, maternal-fetal immune balance, which is related to early spontaneous abortion. Adiponectin affects endometrial receptivity by both paracrine and autocrine pathways. Leptin can regulate the growth and development of zygote through the regulation of gonadotropins secretion. TNF-α can promote the development of embryo by regulating the proliferation and differentiation of trophoblasts. The proinflammatory effect of visfatin is beneficial to the maintenance of pregnancy. Imbalances among ILs lead to the abnormal immune status at the maternal-fetal interface. This paper summarizes the effects of adiponectin, leptin, TNF-α, visfatin and ILs on the pathogenesis of early spontaneous abortion.
Keywords：AbortionspontaneousAdipokinesAdiponectinLeptinTumor necrosis factor -alphaNicotinamide phosphoribosyltransferaseInterleukins
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 57-60 )