The Application of Mitochondrial Function Index in Assisted Reproductive Techniques
WANG Jia-yi
LING Xiu-feng
TONG Hua
Abstract：It is important for assisted reproductive techniques (ART) to choose oocytes with the synchronous development of nucleus and cytoplasm. Mitochondria are cellular organelles that are required for energy production. More and more evidence demonstrated that mitochondria played important roles in oocyte development and reproduction. Mitochondria could be used for measuring the quality of oocyte cytoplasm. The indicators of mitochondria include mitochondria DNA copy number, mitochondria structure and distribution, mitochondrial transmembrane potential, ATP level and ROS level. ART can affect the mitochondria indicators. There are the plenty of ways to protect oocyte mitochondria and improve mitochondrial function, such as mitochondria transplant, polar body transplant, using mitochondria nutrients and so on. There were some successful fertility cases of the mitochondrial transplantation with the allograft or autoplastic mitochondria. Mitochondria nutrients including alpha lipoic acid (ALA), resveratrol, L-carnitine and coenzyme Q10 have been used in clinic.
Keywords：Reproductive techniquesassistedOocytesMitochondriaDNAmitochondrialOxidative phosphorylation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 45-48,65 )