Roles of Prostaglandin E2 and its Receptor in Follicular Development
LIU Kai-lu
CHIAN Ri-cheng
CUI Yu-gui
Abstract：Prostaglandin E2 (PGE2) as one of the key paracrine factors of luteinizing hormone (LH) pathway is mainly expressed by the granulosa cells of the follicles at developmental stages. PGE2 acts at the cumulus cells by binding with two kinds of receptors, the prostaglandin receptor 2 (PTGER2) and the prostaglandin receptor 4 (PTGER4), after PGE2 is secreted to the extracellular. PTGER2 and PTGER4, by activating intracellularly conjugated Gas proteins, activate the adenylate cyclase (AC), and increase the level of intracellular cyclic adenosine monophosphate (cAMP). The transcriptions of hyaluronan synthase 2 (HAS2) and the tumor necrosis factor alpha mediated protein 6 are induced by the increased cAMP, following by the cumulus cells expansion. PGE2 also plays a role in the regulation of corpus function by increasing the expression of aromatase (CYP19) and the level of progesterone. The abnormal regulation of PGE2 is associated with a variety of reproduction-related diseases, such as luteinized unruptured follicular syndrome (LUFS) and fertilization disorders. In this paper, the function of PGE2 in the follicular development and ovulation, and its mechanism, were reviewed.
Keywords：Prostaglandins EReceptorsprostaglandinOvarian follicleOvulationCumulus cells
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 26-30 )