Negative Effect of Elevated Progesterone before hCG Administration on Outcome of in vitro Fertilization
QIAO Zong-hui
LI Dao-jing
PANG Li-e
BAO Man-man
LIU Yu-sheng
TONG Xian-hong
WU Li-min
Abstract：Objective:To explore the impact of the elevated level of serum progesterone before hCG administration on the pregnancy outcome of in vitro fertilization during controlled ovarian stimulation (COS). Methods:The data of 1 132 infertile patients underwent IVF-ET or ICSI-ET treatment from January 2012 to December 2014 in Anhui Provincial Hospital Affiliated to Anhui Medical University were retrospectively analyzed. Those objectives were firstly divided into four groups according to their progesterone levels on the day of hCG administration, group A1:progesterone<3.18 nmol/L(521 cases);group A2:progesterone 3.18-6.36 nmol/L (338 cases);group A3:progesterone>6.36-7.95 nmol/L(197 cases);group A4:progesterone>7.95 nmol/L (76 cases). According to the serum progesterone level that maintained 2 days before hCG administration (including the day of hCG injection and the previous day), those patients were secondly divided into three groups, group B1:progesterone<3.18 nmol/L for two days(220 cases);group B2:progesterone 3.18-6.36 nmol/L for two days (116 cases);group B3:progesterone>6.36 nmol/L for two days (62 cases). The clinical data and the outcomes of IVF/ICSI-ET were compared among those groups. Results:There were no significant differences in the age, the duration of infertility, the total dose of gonadotropin, the gonadotropin days, the number of oocyte retrieval, the normal fertilization rate, the available embryo rate and the high-quality embryo rate among the groups (P>0.05). Compared with the group A1, thebiochemical pregnancy rate, implantation rate, clinical pregnancy rate and live-birth rate in the group A4 were significantly reduced (P<0.008). The implantation rate, clinical pregnancy rate and live-birth rate in the group B2 and the group B3 were much lower than those in the group B1, while the biochemical pregnancy rate in the group B3 was lower than that in the group B1 (P<0.017). Conclusions:In controlled ovarian stimulation, there were negative impacts on the outcome of IVF when the progesterone level >7.95 nmol/L on the day of hCG administration and the maintained two days of progesterone level≥3.18 nmol/L before hCG administration.
Keywords：ProgestinsOvulation inductionPregnancy outcomeChorionic gonadotropinReproductive techniquesassisted
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 9-13 )