Evaluation of Treatment of Zuogui Pill, a Chinese Medicine, for Recurrent Implantation Failure

ZHAO Cui; YANG Liu; ZHANG Xiang; ZHANG Xue-hong; WEI Qing-lin; LI Li-fei

Abstract：Objective:To investigate the clinical effectiveness of Zuogui pill, a Chinese medicine, for those infertility women with recurrent implantation failure (RIF). Methods:Eighty infertility women with RIF were selected, who took frozen-thawed embryo transfer (FET) cycles with GnRHa down-regulation protocol. Patients were randomly divided into two groups: The Chinese medicine group was treated with Zuogui pill, a Chinese medicine (n=40), during down-regulation for 4 cycles, while the control group without Chinese medicine during their cycles (n=40). The pregnancy rate, the levels of serum hormones, the echo of EMI and endometrial blood flow under B ultrasound were assessed. Results:The levels of serum E2, LH and P on the day of hCG administation were not significantly different between the Chinese medicine group and the control group (P>0.05). The clinical pregnancy rate and the level of serum E2 in the group treated with Zuogui pill were significantly higher than those in the control group (P<0.05). Compared with control group, the Chinese medicine group had better endometrial blood flow RI and echo of EMI (P<0.05), and no significant changes in blood flow PI and blood branches of endometrium (P>0.05). Meanwhile, the adverse reaction in the Chinese medicine group, such as hot flashes and weakness of the lumbar region, were lower (P<0.05). Conclusions:Our data showed that the Zuogui pill may be benefit for the treatment of RIF, with balance of serum hormones, improvement of endometrial blood flow, and the improved clinical outcomes.