Analysis of Correlation between Surgical Timing and Pregnancy Outcomes of Intrauterine Artificial Insemination

LI Si-chen; WU Yi-xuan; LIU Jian-qiao; ZHANG Wei-liang

Abstract：Objective: To investigate the correlation between the surgical timing of insemination and the pregnancy rate of intrauterine artificial insemination (IUI). Methods:The retrospective analysis was designed in 851 infertile couples with male factors who were treated with IUI (a total of 1 751 cycles). Those cycles were divided into four groups as follows: Group 1 was one time of IUI before ovulation, Group 2 was one time of IUI after ovulation, Group 3 was two times of IUI before ovulation, and Group 4 was two times of IUI before and after ovulation individually. The pregnancy rates of four groups were then compared accordingly. Results: The pregnancy rates in group 1 and group 2 were 11.21%and 12.23%, while in group 1 the pregnancy rate in couples with ovulation after IUI was significantly higher than that in those couples with anovulation (P<0.05). The pregnancy rates in group 3 and group 4 were 16.21%and 15.65%, while in group 3 the pregnancy rate in couples with ovulation after IUI was significantly higher than that in those couples with anovulation (17.14%vs. 0.00%, P=0.040). In the ovulatory cycles of four groups, the pregnancy rates were 10.99%, 12.23%, 17.14% and 16.21%respectively (P>0.05). The pregnancy rate of two times of IUI was higher than that of one time of IUI (although P>0.05). Conclusions: There are not significant difference in the pregnancy rate in those couples with ovulation before or after IUI treatment, 1 or 2 times of IUI. However, the pregnancy rate is very low in those couples without ovulation before or after IUI treatment (0~2.85%). Those women with the luteinized unruptured follicle syndrome (LUFS) during two cycles of IUI should be advised to treat with in vitro fertilization (IVF).