Research Progress of Mitogen-activated Kinase Phosphatase-1 in Obstetrical and Gynecological Related Diseases
SU Lin
CHEN Qiong-hua
Abstract：The mitogen-activated kinase phosphatase (MKPs), a intracellular phosphatase family that could hydrolyze the mitogen-activated protein kinases (MAPKs) in cells, participate in the regulation of cell stress, differentiation, proliferation and apoptosis by the negative feedback regulation of MAPKs. The abnormal expression of MKP-1 was associated with the cancer occurrence and development. MKP-1 shows the strongest ability of dephosphorylation, which has been well studied as a member of the MKPs family. In this review, we summarized the effects of MKP-1 in the diseases associated with obstetrics and gynecology, including genital neoplasms, endometriosis and preeclampsia. The expression pattern, pathological function and molecular mechanism of MKP-1 in obstetrical and gynecological diseases were elucidated. After that, we focused on the pathophysiological effect of MKP-1 in endometriosis. The interaction between MKP-1 and MAPKs could provide us more references for the prospective research.
Keywords：Mitogen-activated protein kinasesDual specificity phosphatase 1Genital neoplasmsfemaleEndometriosisPre-eclampsia
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 155-159 )