Wnt Signal Pathway during Folliculogenesis
ZHOU Tuan-ping
CUI Yu-gui
QIAN Ri-cheng
Abstract：The transduction of Wnt signal involves the interaction between Wnt and Fzd as well as cooperation with single-pass co-receptors, which induces the β-catenin translocation to nucleus and the transcription of target genes. This Wnt pathway drives the proliferation of granulosa cells via the intracellular β-catenin translocation. Wnt4 is a pleiotropic player during prenatal and postnatal follicular development, maturation and survival. Fzd1 participates in regulating the expression of those genes involved in cumulus expansion. β-catenin also participates in steroidogenesis and luteogenesis. The maladjustment of β-catenin may lead to premature ovarian failure,granulosa cell tumors and luteal phase defects. In this review, we summarized the classical Wnt/β-catenin pathway and its roles in folliclogenesis.
Keywords：Signal transductionOvarian follicleSteroidsHormonesOvulationLuteinization
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 128-131 )