N6-methyl-adenosine (m6A) in RNA Modifications and Gametogenesis
DU Lin-qing
XU Jia-wei
SUN Ying-pu
Abstract：N6-methyl-adenosine (m6A),one of the most common modifications of more than 100 methylation on RNA molecules, plays an important biological role. With the application of the m 6A RNA immunoprecipitation approach followed by high-throughput sequencing (MeRIP-SEQ) and the discovery of three kinds of proteins, methyltransferase,demethylase and m6A-binding proteins, the m6A was identified to be a kind of dynamic and reversible modification of RNA methylation. The m6A plays its roles just via the"writing", "erasering"and "reading" methyl of RNA by the above three kinds of proteins. To our knowledge,m6A regulates many biological procedures, such as gametogenesis,gonadal development, embryo development, as well as RNA metabolism. This reversible RNA methylation is a post-transcriptional regulation of gene expression, especially in the gametogenesis, which is a new research field in reproductive medicine.
Keywords：N6-methyl-adenosineMethylationEpigenesisGametogenesisEmbryonic development
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 410-414 )