Reproductive Toxicity of Benzo(a) pyrene
LIAN Li-fen
CHEN Ya-qiong
HOU Hai-yan
Abstract：Polycyclic aromatic hydrocarbons(PAHs), a series of common air pollutants mainly from tobacco smoke,coal burning,vehicle exhaust and indoor cooking fumes, are easily accumulated in water,soil and crop. Benzo ( a ) pyrene ( BaP ) is the representative environmental organic pollutants of PAHs . A large number of epidemiological investigations and animal experiments showed that BaP was related to the adverse pregnancy outcomes,such as reduced fertility,infertility,miscarriage,premature birth,fetal growth restriction and fetal birth defects. The mechanisms of BaP effects could include the cytochrome P450 enzyme metabolism ,cell cycle progression,DNA damage, and anti-estrogen effect.
Keywords：Benzo(a)pyreneReproductionOxidative stressCell cycleDNA damageEndocrine disruptors
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 450-453 )