The Correlation between IVF Methods and Monozygotic Twins Gestation
FAN Wen-qian
SUN Ying-pu
SU Ying-chun
GUO Yi-hong
Abstract： Objective: To investigate the correlation between those risk-factors of in vitro fertilization-embryo transfer(IVF-ET)and monozygotic twins(MZT)gestation. Methods:3 966 clinical pregnancy cycles, including 36 MZT cycles,were analyzed by Logistic regression. According to fertilization methods and with or without laser-assisted hatching(LAH),total of 11 423 IVF/intracytoplasmic sperm injection(ICSI)cycles were divided into nonAH-IVF group (4 624 cases),nonAH-ICSI group (1 571 cases),LAH-IVF group (3 807 cases)and LAH-ICSI group(1 421 cases). The incidences of MZT were compared. Results:LAH-ISCI(OR=1.039,95%CI:1.013~1.065)may be a risk factor of MZT pregnancy in IVF-ET. There were no significant differences in general condition between nonAH groups and LAH groups,and no significant differences in clinical pregnancy rate(40.72%vs. 42.76%)and MZT rate(0.69%vs. 0.75%)between nonAH-IVF group and nonAH-ICSI group (P>0.05). MZT rate was significantly higher in LAH-ICSI group than that in LAH-IVF group (2.31%vs. 0.66%,P<0.05),while there was no significant difference in the pregnancy rate between the two groups(27.97%vs. 29.77%,P>0.05). Conclusions:LAH-ICSI might increase the occurrence of MZT.
Keywords：Fertilization in vitroEmbryo transferLasersEmbryo culture techniquesTwinsmonozygoticZona pellucidaMicromanipulationPregnancy rate
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 275-277,308 )