Immune-Inflammatory Thrombotic Mechanism of Recurrent Spontaneous Abortion Caused by Antiphospholipid Syndrome
ZHAO Jia-run
ZHENG Shu-chang
WANG Yi-di
WANG Cheng-xia
HE Jun-qin
Abstract：The etiology of recurrent spontaneous abortion(RSA)is complex and diverse.Among them,the immune disease antiphospholipid syndrome(APS),as a high-risk factor for thrombosis,mainly leads to adverse pregnancy outcomes through the immune-inflammatory thrombosis mechanism.APS mainly initiates the immune-inflammatory thrombosis cascade reaction through antiphospholipid antibodies(aPLs).That is,there is a functional imbalance among decidual natural killer cells,decidual macrophages,and regulatory T cells,and an excessive release of pro-inflammatory factors such as tumor necrosis factor-α(TNF-α)and interferon-γ(IFN-γ),which damage the vascular endothelium.Subsequently,it activates signaling pathways such as Janus kinase(JAK)-signal transducer and activator of transcription(STAT)and nuclear factor-κB(NF-κB),activates the complement system,damages the vascular endothelium,promotes local thrombosis,and leads to an imbalance in the immune microenvironment at the maternal-fetal interface.Therefore,based on the in-depth analysis of the pathological mechanism of immune-inflammatory thrombosis,this paper reviews the occurrence mechanism and clinical treatment progress of RSA caused by APS,aiming to provide reference for future research,a new entry point for implementing new diagnosis and treatment plans,and a theoretical basis and clinical practice reference for targeted drug diagnosis and treatment of RSA complicated with APS.
Keywords：AbortionhabitualAntiphospholipid syndromeCytokinesImmunityThromboinflammation
Publication Date：2026-02-15
Online Publishing Date：2026-03-24(First online date of this platform, not the publication date of the document)
Pages：5( 103-107 )