Mechanisms of Neonatal Respiratory Distress Syndrome Associated with Gestational Diabetes Mellitus
ZHANG Xing-ying
YI Feng-xin
WANG Peng-yuan
HAO Wei
Abstract：Gestational diabetes mellitus(GDM)is a common metabolic disease during pregnancy.It not only increases the risk of preeclampsia,postpartum hemorrhage,and type 2 diabetes mellitus in pregnant women,but also makes the offspring prone to adverse outcomes.Neonatal respiratory distress syndrome(NRDS)is common in infants of mothers with GDM.Studies have shown that the pathological mechanisms of NRDS in infants of GDM mothers involve multiple interrelated pathways:oxidative stress caused by maternal hyperglycemia,systemic inflammatory response,disruption of pulmonary surfactant synthesis,and changes in epigenetic modifications.This review summarizes the latest progress in the mechanisms of NRDS in infants of GDM mothers,aiming to reduce the incidence of NRDS and improve perinatal health outcomes.
Keywords：DiabetesgestationalRespiratory distress syndromenewbornPulmonary surfactantsOxidative stressInsulin
Publication Date：2026-02-15
Online Publishing Date：2026-03-24(First online date of this platform, not the publication date of the document)
Pages：5( 98-102 )