Research Progress on Nrf2 and Oxidative Stress in Preeclampsia
REN Yu-xi
HU Li-yan
REN Yan-xu
Abstract：Oxidative stress is a key pathophysiological mechanism in preeclampsia.Therefore,antioxidant stress holds significant importance for the prevention and treatment of preeclampsia and its related complications.This paper systematically reviews the molecular mechanisms and pathophysiological significance of nuclear factor-erythroid 2-related factor 2(Nrf2)in regulating oxidative stress in preeclampsia.Recent studies have found that the signaling pathway constituted by Nrf2 and its negative regulatory protein,Kelch-like ECH-associated protein 1(KEAP1),is frequently dysregulated or functionally impaired in placental tissues of preeclampsia patients and in animal models.This impairment leads to the inhibited transcriptional activation of downstream antioxidant genes,such as heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1,thereby exacerbating placental oxidative damage.Further research indicates that Nrf2 not only regulates the gene expression profile driven by the antioxidant response element(ARE)but also participates in placental formation and remodeling by influencing vascular endothelial cell function and trophoblast apoptosis.Nrf2 is a key nodal molecule linking oxidative stress to the pathological progression of preeclampsia,and its activation status is closely associated with disease severity and progression.
Keywords：Pre-eclampsiaOxidative stressPlacentaEndothelial cellsNuclear factor-erythroid 2-related factor 2
Publication Date：2026-02-15
Online Publishing Date：2026-03-24(First online date of this platform, not the publication date of the document)
Pages：4( 89-92 )