Research Progress on the Treatment of Endometriosis with Mesenchymal Stem Cells
ZHANG Xiu-xia
WU Xue-li
MA Yue
LI Hong-li
LIU Chang
Abstract：Endometriosis(EMs)is a common gynecological disease.Traditional treatment methods have limitations such as high recurrence rates and damage to ovarian function.Mesenchymal stem cells(MSCs)have emerged as a novel therapeutic approach due to their multi-directional differentiation potential and immunomodulatory properties.This review summarizes the dual roles of MSCs in EMs:pathogenic MSCs drive disease progression through abnormal proliferation and fibrosis,while therapeutic MSCs exert effects through mechanisms such as immunomodulation and anti-angiogenesis.The review focuses on the progress of strategies such as stem cell transplantation,cell-free therapy,gene modification,and combination therapy,and analyzes the challenges in clinical translation,including drug delivery safety,long-term efficacy,and standardization issues.Future research should optimize the delivery system and improve the evaluation criteria to promote the clinical application of MSC therapy.
Keywords：Mesenchymal stem cellsEndometriosisMesenchymal stem cell transplantationExosomesImmunomodulation
Publication Date：2026-02-15
Online Publishing Date：2026-03-24(First online date of this platform, not the publication date of the document)
Pages：7( 53-59 )