Research Progress on the cGAS-STING Signaling Pathway in Ovarian Cancer
SUN Ya-ge
ZHANG Yun-feng
LU Yue
GUO Jing-jing
XIANG Xiao-ying
JIA Han
WANG Yue
Abstract：Ovarian cancer(OC)is the gynecological malignant tumor with the highest mortality rate.Most patients are diagnosed at an advanced stage and have a poor prognosis.The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway,as a core hub of innate immunity,triggers type Ⅰ interferon response by recognizing abnormal cytoplasmic DNA and plays a crucial role in regulating anti-tumor immunity and the tumor microenvironment.This pathway shows a"double-edged sword"characteristic in OC.Acute activation can enhance anti-tumor immunity through mechanisms such as enhancing antigen presentation by dendritic cells and promoting CD8+T cell infiltration.Chronic and persistent activation promotes tumor progression by driving the non-classical nuclear factor-κB pathway.Additionally,this pathway in OC is often inactivated due to factors such as epigenetic silencing or inhibition by metabolites,further weakening immune surveillance.Based on its bidirectional regulatory characteristics,STING agonists and their combined application with immune checkpoint inhibitors,poly(ADP-ribose)polymerase inhibitors,chemotherapy,or oncolytic viruses provide new directions for the treatment of OC.
Keywords：Ovarian neoplasmsCyclic GMPInterferon type ⅠImmunityinnateTumor escapeSTING agonist
Publication Date：2025-12-15
Online Publishing Date：2026-01-13(First online date of this platform, not the publication date of the document)
Pages：6( 696-701 )