Research Progress on the Intervention of Ovarian Cancer by Chinese Medicine Monomers and Compounds through Regulating the NF-κB Signaling Pathway
XIE Jiu-mei
WANG Yu
CHEN Xiang-nan
ZHANG Li-qian
WU Xiao-ke
Abstract：Ovarian cancer(OC)is one of the common malignant tumors in the female reproductive system.Its early stage symptoms are insidious,and most patients are diagnosed at an advanced stage,which seriously threatens the lives and health of patients.Currently,the treatment of OC mainly includes surgery and chemotherapy,but problems such as drug resistance,recurrence and adverse reactions are prone to occur.Therefore,it is urgent to seek safer and more effective treatment strategies.In recent years,Chinese herbal medicine has attracted wide attention due to its high efficiency and no obvious toxic side effects,and has become a research hotspot in the field of oncology.The nuclear factor-κB(NF-κB)signaling pathway plays a crucial role in the processes of OC cell proliferation,apoptosis,metastasis and invasion.Its continuous abnormal activation is closely related to the occurrence and development of OC.Studies have shown that Chinese medicine can inhibit the progression of OC by regulating the NF-κB signaling pathway,providing new ideas for the prevention and treatment of OC.This article summarizes the current research status of Chinese medicine monomers and compounds in the treatment of OC by regulating the NF-κB signaling pathway through reviewing relevant domestic and foreign literature in recent years,aiming to provide a scientific theoretical basis for the clinical research and drug development of OC.
Keywords：NF-kappa BOvarian neoplasmsDrugsChinese herbalTraditional Chinese medicine monomerTraditional Chinese medicine compound
Publication Date：2025-12-15
Online Publishing Date：2026-01-13(First online date of this platform, not the publication date of the document)
Pages：6( 690-695 )