Research Progress on Delta-Like Ligand 4 in Gynecological Malignancies
BAI Yao-jun
WANG Si-yao
LI Hong-li
LIU Chang
Abstract：Cervical cancer,ovarian cancer and endometrial cancer are important causes of female mortality.Although standardized treatment can improve the condition of some patients,a considerable proportion of patients still have a poor prognosis and continuous disease progression.Early diagnosis and treatment are key strategies to improve the prognosis of patients with gynecological malignancies and reduce the disease burden.Therefore,exploring more effective therapeutic targets is of great significance.Delta-like ligand 4(DLL4),as a key ligand of the Notch signaling pathway,plays an important role in tumor angiogenesis,tumor stem cell maintenance,and immune environment regulation.In recent years,studies have found that DLL4 is significantly highly expressed in various gynecological malignancies such as ovarian cancer,cervical cancer and endometrial cancer,and its expression level is closely related to tumor stage,metastasis and poor prognosis,showing the potential as a novel targeted therapeutic target.This article systematically elaborates on the biological functions of DLL4 and reviews the research progress on the correlation between DLL4 and the three major gynecological malignancies,aiming to provide new ideas for the precise treatment of gynecological malignancies.
Keywords：ReceptorsNotchGenital neoplasmsfemaleAngiogenesis inhibitorsAntineoplastic combined chemotherapy protocolsDelta-like ligand 4
Publication Date：2025-12-15
Online Publishing Date：2026-01-13(First online date of this platform, not the publication date of the document)
Pages：6( 680-684,707 )