Association between Preeclampsia and the Occurrence of Congenital Heart Disease in Offspring:A Prospective Study Based on the Chinese Birth Cohort from 2018 to 2022
LIU Jian-hui
YIN Cheng-hong
LIU Rui-xia
SU Shao-fei
ZHU Hui-ping
XIE Shuang-hua
ZHANG En-jie
Abstract：Objective:To analyze the relationship between preeclampsia(PE)in pregnant women and the risk of congenital heart disease(CHD)in their offspring,based on the Chinese Birth Cohort from 2018 to 2022.Methods:This was a prospective cohort study.Pregnant women who participated in the"Chinese Birth Cohort"study from February 2018 to December 2022 were selected as the study subjects.An electronic data collection system was used to collect baseline and follow-up information.A multivariate logistic regression model was used to analyze the association between PE in pregnant women and the risk of CHD in their offspring.Results:A total of 152 151 singleton pregnant women were included in this study.The average age of all pregnant women was(30.66±4.11)years.The incidence of CHD in offspring was 0.88％(1 340 cases).There were 4 565 pregnant women with PE in this study,with an incidence of 3.00％.The incidence of CHD in the offspring of pregnant women with PE was significantly higher than that of pregnant women without PE(1.31％vs.0.87％,P=0.002).The results of the multivariate logistic regression model analysis showed that PE in pregnant women was significantly associated with the occurrence of CHD in offspring(OR=1.434,95％CI:1.101-1.868,P=0.008).PE was positively associated with the occurrence of ventricular septal defect(OR=1.513,95％CI:1.047-2.185,P=0.027),persistent left superior vena cava(OR=3.683,95％CI:1.647-8.232,P=0.002),and patent foramen ovale(OR=3.158,95％CI:1.642-6.075,P=0.001)in offspring.Conclusions:PE in pregnant women may increase the risk of CHD in their offspring.
Keywords：Pre-eclampsiaHeart defectscongenitalCohort studiesLogistic models
Publication Date：2025-12-15
Online Publishing Date：2026-01-13(First online date of this platform, not the publication date of the document)
Pages：4( 664-667 )