Research Progress on the Influence of Maternal Metabolism and Gestational Nutrition on Gut Microbiota
ZHAO Xiao-wei
JIANG Lu
Abstract：The influence of gestational nutrition on the maternal gut microbiota and fetal development is a hot-topic in clinical research.Increasing attention has been paid to the impact of the maternal internal environment on fetal development and the long-term health of offspring.Traditionally,it was believed that fetal development was mainly dominated by genetic programs.However,studies have shown that the fetus has complex perception and learning abilities,and the maternal nutritional and metabolic status is a key factor determining the health of offspring.Based on the"thrifty phenotype hypothesis",intrauterine malnutrition in the fetus can increase the risk of metabolic diseases in adulthood through metabolic reprogramming.Gestational nutrition has a profound impact on fetal developmental programming and the long-term health of offspring by reshaping the gut microbiota and its metabolite profile.This review summarizes the dynamic changes in gut microbiota during pregnancy,the hormonal and immune regulatory mechanisms,and the effects of different dietary patterns on the gut microbiota and the health of mothers and infants.
Keywords：Pregnant womenGastrointestinal microbiomeMicrobiotaPrenatal nutritional physiological phenomenaMetabolism
Publication Date：2025-10-15
Online Publishing Date：2025-11-26(First online date of this platform, not the publication date of the document)
Pages：5( 563-566,580 )