Research Progress on Glucose and Lipid Metabolism in Decidualization of Endometrial Stromal Cells in Patients with PCOS
ZENG Hui-fang
DOU Zhen
LI Yu-xin
JIANG Xin-yu
XIA Tian
Abstract：Polycystic ovary syndrome(PCOS)is a common endocrine and metabolic disease among women of reproductive age.The imbalance of glucose and lipid metabolic homeostasis in PCOS can interfere with decidualization process of endometrial stromal cell(ESC)and significantly increase the risk of adverse pregnancy outcomes.Studies have found that in terms of glucose metabolism,there are abnormal mechanisms in patients with PCOS,such as abnormal epigenetic regulation,insulin signaling pathway transduction disorders,and the influence of hyperandrogenism on endoplasmic reticulum stress.In terms of lipid metabolism,hyperandrogenism acts on the Wilms tumor 1-very low density lipoprotein receptor(WT1-VLDLR)pathway,leading to abnormal lipid storage,and the disorder of PCOS-related adipokines inhibits ESC decidualization.This review summarizes the mechanisms of abnormal glucose and lipid metabolism during the decidualization of ESC in patients with PCOS,providing a theoretical basis for in-depth research on the metabolic factors of reproductive disorders in PCOS and the further development of treatment strategies targeting metabolic remodeling.
Keywords：Polycystic ovary syndromeEndometriumStromal cellsGlucose metabolism disordersLipid metabolism disordersDecidualization
Publication Date：2025-10-15
Online Publishing Date：2025-11-26(First online date of this platform, not the publication date of the document)
Pages：6( 534-539 )