Research Progress on the Regulation of Cervical Cancer HeLa Cells by Traditional Chinese Medicine Monomers Based on the PI3K/Akt Signaling Pathway
SHANG Jing-ying
LIU Tong-tong
GU Xu-meng
WANG Jia-meng
CONG Hui-fang
Abstract：Cervical cancer is one of the most common gynecological malignancies.The phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)signaling pathway is one of the signal transduction pathways closely related to cervical cancer.Studies have found that quercetin,luteolin,triterpenoids from Inonotus obliquus,tubeimoside Ⅰ,and neferine can inhibit the activation of the PI3K/Akt pathway,reduce the phosphorylation levels of PI3K and Akt,and induce apoptosis in HeLa cells.Wogonin,rotenone,saikosaponin A,lycorine,camptothecin,shikonin,and artemisinin activate pro-apoptotic proteins and autophagic complexes through this pathway,promoting cell autophagy and apoptosis.Paeonol,oxymatrine,and protopanaxadiol inhibit cell migration and invasion by regulating the epithelial-mesenchymal transition mediated by the PI3K/Akt signaling pathway.Arsenic trioxide,paclitaxel,and gambogic acid can block this pathway,reduce the expression of angiogenesis-related proteins,and inhibit tumor angiogenesis.Pterostilbene down-regulates the expression of mammalian target of rapamycin through this pathway,affecting the tumor microenvironment.Traditional Chinese medicine monomers affect the proliferation,apoptosis,autophagy,migration,invasion of HeLa cells and the tumor microenvironment by regulating the PI3K/Akt signaling pathway,providing new therapeutic perspectives and theoretical basis for cervical cancer.
Keywords：Uterine cervical neoplasmsHeLa cellsPhosphatidylinositol 3-kinasesProtein-serine-threonine kinasesSignal transduction
Publication Date：2025-10-15
Online Publishing Date：2025-11-26(First online date of this platform, not the publication date of the document)
Pages：7( 498-504 )