Research Progress of LncRNA HOTAIR in Gynecological Malignant Tumors
ZHOU Ling-ling
SONG Jian-dong
Sarina
Abstract：With the rapid development of high-throughput sequencing technology,the role of long non-coding RNA(lncRNA)HOX transcript antisense RNA(HOTAIR)in gynecological malignant tumors has been gradually revealed.Studies have shown that HOTAIR is generally highly expressed in cervical cancer,ovarian cancer,and endometrial cancer,and is closely related to tumor progression,metastasis,and drug resistance.HOTAIR participates in the processes of tumor proliferation,invasion,metastasis,and drug resistance by regulating signaling pathways such as Wnt/β-catenin,transforming growth factor-β(TGF-β)/epithelial-mesenchymal transition(EMT),Notch,and phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt).In addition,its genetic polymorphisms(such as single nucleotide polymorphisms)are closely related to the susceptibility of gynecological malignant tumors.Its characteristic of regulating microRNA function as a competing endogenous RNA(ceRNA)further highlights its key role in tumor molecular regulation.HOTAIR can not only serve as a potential molecular marker for the diagnosis and prognostic evaluation of gynecological malignant tumors,but may also become an important target for future individualized treatment strategies.
Keywords：RNAlong noncodingOvarian neoplasmsUterine cervical neoplasmsEndometrial neoplasmsDrug resistanceneoplasmSignal transductionCell proliferationHOTAIR
Publication Date：2025-10-15
Online Publishing Date：2025-11-26(First online date of this platform, not the publication date of the document)
Pages：5( 481-485 )