Research Progress on the Role of ATP Citrate Lyase in Recurrent Spontaneous Abortion
REN Xiang-ning
LI Ping
Abstract：Recurrent spontaneous abortion(RSA)is a complication of pregnancy,and its occurrence is related to many factors,such as abnormalities immune function,anatomical structure,chromosomal abnormalities,and endocrine abnormalities.Some targeted drugs have achieved certain curative effects in the treatment of RSA.Studies have shown that ATP citrate lyase(ACLY)can affect cell proliferation and function through intracellular metabolic pathways such as glucose metabolism and lipid metabolism.It can also mediate the expression of relevant cytokines through histone acetylation,thereby influencing the proliferation of immune cells and immune regulation,and participating in epigenetic regulation.This review summarizes the potential mechanism of action of ACLY in RSA,aiming to provide new theoretical basis for the targeted therapy of RSA.
Keywords：ATP citrate(pro-S)-lyaseAbortionhabitualImmunitycellularCytokinesCell metabolism
Publication Date：2025-08-15
Online Publishing Date：2025-09-23(First online date of this platform, not the publication date of the document)
Pages：5( 384-388 )