The Impact of Liver Cirrhosis in Pregnancy on Adverse Maternal and Infant Outcomes:A Meta-Analysis
PAN Zhi-xiu
GAO Shuang
SHI Ke
ZHANG Xiu-ping
WANG Fu-ling
Abstract：Objective:To explore the adverse outcomes and their impacts on both mothers and fetuses resulting from pregnancy complicated by liver cirrhosis.Methods:Computerized searches of CNKI,WanFang Data,VIP,SinoMed,PubMed,Web of Science,and the Cochrane Library were conducted to collect relevant studies on liver cirrhosis in conjunction with pregnancy from the time of establishment until June 2024.A statistical meta-analysis was performed using RevMan 5.4 and Stata 16.0 software.Results:A total of 21 studies were included in the literature review,encompassing 8 958 patients with cirrhosis during pregnancy across six countries.The meta-analysis revealed that women with cirrhosis faced a significantly higher risk of adverse maternal and infant outcomes.These outcomes included cesarean section(OR=2.57,95％CI:2.07-3.18),post-partum hemorrhage(OR=4.29,95％CI:3.41-5.40),hypertensive disorders in pregnancy(OR=4.12,95％CI:1.95-8.71),gestational diabetes mellitus(OR=2.08,95％CI:1.56-2.79),fetal death(OR=2.87,95％CI:2.04-4.04),and preterm labor(OR=5.19,95％CI:3.51-7.69).Conclusions:Cirrhosis during pregnancy may elevate the risk of adverse maternal and fetal outcomes.However,further research is necessary to more accurately identify the risk factors associated with these negative outcomes.
Keywords：PregnancyLiver cirrhosisPregnancy outcomeFetal growth retardationMeta-analysis
Publication Date：2025-06-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 293-301 )