The Role of Thrombospondin-1 in the Pathogenesis of Preeclampsia
REN Sheng
WANG Yong-hong
Abstract：Preeclampsia(PE)is a pregnancy-specific disorder and one of the leading causes of maternal mortality and neonatal morbidity.To date,the etiology and pathogenesis of PE remain incompletely elucidated.Insufficient trophoblast invasion leading to impaired uterine spiral artery remodeling,aberrant placental development,and vascular endothelial dysfunction are key factors contributing to the pathogenesis of PE.Thrombospondin-1(TSP-1),a multi-domain and multi-functional extracellular matrix glycoprotein secreted by various human cells,interacts with multiple cell surface receptors and plays a role in regulating diverse physiological and pathological processes,including angiogenesis,inflammatory responses,platelet activation,cellular invasion,and immune responses,and the occurrence and development of hypertension and hyperlipidemia.Recent studies have demonstrated elevated expression levels of TSP-1 in both the placenta and maternal serum of patients with PE.Consequently,TSP-1 may be one of the contributing factors to the pathogenesis of PE.This review aims to summarize the role of TSP-1 in the pathophysiology of PE,providing new ideas for its diagnosis and treatment.
Keywords：Pre-eclampsiaThrombospondin 1EndotheliumvascularOxidative stressNeovascularizationphysiologic
Publication Date：2025-06-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 275-279 )