Progress in Immunological of Endometriosis and Pain Sensitization

YIN Ting; CONG Hui-fang

doi:10.12280/gjfckx.20240986

Abstract：Endometriosis(EMs)is a gynecological chronic disease characterized by chronic pelvic pain,dysmenorrhea,dyspareunia and abnormal menstruation,which is common in women of childbearing age.The pain of this disease is refractory and progressive,which seriously affects the quality of life of patients.In recent years,some studies have shown that abnormal immune response is related to the occurrence of this disease and related pain sensitization.The immune cells involved in EMs-associated pain sensitization mainly include macrophages,mast cells,microglia and neutrophils.Inflammatory factors such as interleukin,tumor necrosis factor-α,nerve growth factor and brain-derived neurotrophic factor play an important role in the process,which form the pathological environment of"inflammation-immune-nerve"under the pathological condition of EMs,leading to the occurrence of pain sensitization of this disease.The purpose of this article is to review the current research progress on the immunological mechanism of EMs-associated pain sensitization,in order to reveal the immune mechanism behind EMs-associated pain sensitization and provide theoretical basis for its clinical prevention and treatment.