Single-Cell RNA Sequencing Analysis of the Angiogenesis Mechanism in Endometriosis
CAO Xiu-rong
ZHOU Wen-bai
FAN Xiang
WANG Yi-fei
ZHU Peng-feng
Abstract：Endometriosis(EMs),as a disease with an unclear etiology,urgent to clarify its pathogenesis with the help of emerging new technologies.The application of single-cell RNA sequencing(scRNA-seq)technology in the research of EMs can obtain complete information about the differentiation,development,evolution,and intercellular interactions from the perspective of individual cells,to help to form a more comprehensive understanding of the pathogenic mechanism of EMs.This article reviews the emerging scRNA-seq technology and the research progress related to angiogenesis in EMs obtained through scRNA-seq in recent years.From multiple perspectives that affect angiogenesis,such as cellular dysfunction and immune imbalance,this article details the relationship between the associated cells of EMs and disease biological mechanisms such as angiogenesis,immune microenvironment changes,hormone responsiveness,and fibrosis,provides new ideas for exploring the pathogenesis of angiogenesis in EMs and finds new therapeutic targets.
Keywords：Sequence analysisRNAHigh-throughput nucleotide sequencingEndometriosisHeteroplasmySingle-cell RNA sequencingAngiogenesis
Publication Date：2025-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 199-205 )