The Progress of Mendelian Randomization in the Study of the Causal Relationship between Exposure Factors and Cervical Cancer
GUO Jing
ZHANG Mao-xiang
ZHOU Chun-he
LIU Si-ning
LI Hui-yan
Abstract：Understanding the potential risk factors is crucial for preventing the occurrence of cervical cancer.Inferring the causality relationships between risk factors and diseases often uses randomized controlled trials and observational studies,but in practice,there are some limitations in both cases.In recent years,Mendelian randomization(MR)has gained attention in cancer research,offering new perspectives for identifying risk factors and exploring potential treatments.MR uses genetic variants as instrumental variables to simulate analysis the relationship between modifiable risk factors and diseases,enabling causal inference in epidemiological studies.This review summarizes the research progress of MR in cervical cancer,summarizes the intrinsic connections between various risk factors and the risk of cervical cancer,and discusses the practice and application of MR analysis in the field of cervical cancer research.
Keywords：Uterine cervical neoplasmsRisk factorsMendelian randomization analysisCausalityInstrumental variables
Publication Date：2025-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 169-174 )