Advances in the Pathogenesis of Fetal Growth Restriction by HMGA2
HOU Chun-yan
DU Xiu-ping
WANG Hong-hong
HOU Yue-yang
Abstract：Fetal growth restriction(FGR)is one of the major pregnancy complications leading to stillbirth and adverse outcomes in newborns,with complex pathogenesis and limited clinical treatment.High-mobility group protein A2(HMGA2),a non-histone chromatin protein,plays a key role in embryonic development,angiogenesis and apoptosis regulation.Recent studies have shown that HMGA2 may be involved in the pathological process of FGR by regulating angiogenesis,endothelial cell function and multi-organ development-related signalling pathways.This article reviews the research progress of HMGA2 in the pathogenesis of FGR and explores its potential role in placental function,foetal hypoxia tolerance and organ development,with aim of providing a new theoretical basis and intervention strategy for the early prediction,diagnosis and targeted treatment of FGR.The in-depth study of the function of HMGA2 and its regulatory network will not only helps to reveal the molecular mechanism of FGR,but also lays an important foundation for the development of precision medicine therapeutic solutions in the future.
Keywords：Fetal growth retardationFetal developmentHMGA2 proteinSignal transductionVascular endothelial growth factors
Publication Date：2025-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 127-131 )