The Role of SOCS1 and Exosomal MicroRNA in the Pathogenesis of Preeclampsia
ZHANG Wen
LIU Hui-qiang
Abstract：Preeclampsia(PE)is a serious complication of pregnancy whose main symptoms include hypertension and multi-system organ damage,which seriously affects the health of mother and child.Termination of pregnancy is currently the preferred treatment choice for PE.Although the pathogenesis of PE has not been completely clarified,recent studies have shown that exosomes from different sources and the microRNAs(miRNAs)they carry play key roles in the development of PE,especially miRNAs,as the most representative type of exosomal small RNAs,can be involved in the pathophysiological process of PE through the regulation of trophoblast function and signaling pathways.In particular,exosomes miRNAs can inhibit suppressor of cytokine signaling 1(SOCS1),thereby regulating the maternal immune responses.In addition,exosomal miRNAs show potential in the early diagnosis of PE and are expected to be biomarkers for the prediction of PE.
Keywords：ExosomesMicroRNAsExosomal small RNAPre-eclampsiaSuppressor of cytokine signaling 1 proteinPathogenesis
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 94-98,109 )