Advances in Exosome-Based Therapy for Chronic Endometritis by Modulating the Immune Microenvironment
LI Heng-bing
YUAN Hai-ning
ZHANG Yun-jie
ZHANG Jiang-lin
GUO Zi-zhen
SUN Zhen-gao
Abstract：Chronic endometritis(CE)is characterized by abnormal infiltration of CD 138+endometrial stromal plasma cells.This persistent inflammatory state can disrupt immune cell infiltration,cytokine expression,and endometrial decidualization,negatively impacting embryo implantation and attracting significant research interest.Exosomes,nano-sized vesicles mediating intercellular communication,have shown considerable promise in modulating the immune microenvironment.This review summarizes the progress of exosome-based therapies for CE,focusing on their mechanism of action in improving the endometrial microenvironment through immune modulation.This may guide the development of novel therapeutic strategies for CE.
Keywords：ExosomesEndometritisLymphocytesCellular microenvironmentEmbryo implantationTherapy
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 72-78 )