Association and Mechanism of Aged Oocytes Quality and Telomerase
YUAN Hai-ning
MU Zhen-ni
ZHANG Jiang-lin
LI Heng-bing
ZHANG Yun-jie
SUN Zhen-gao
Abstract：Oocyte quality is a crucial determinant in the assessment of fertility,which is closely correlated to age.The quality of oocytes declines in women after 35 years old,accompanied by an accelerated decrease in fertility.Telomerase,a ribonucleoprotein complex composed of catalytic protein subunits and RNA components,etc.,maintains telomere length and stability,which is associated with the quality of oocytes in aged women.Telomeres can influence the activity of telomerase through the telomere protective protein complex and telomeric repeat sequence RNA.Additionally,aging can cause changes in the activity of telomerase in female oocytes.The effects of altered telomerase activity on the quality of aged oocytes are mainly manifested in three aspects of oocyte meiosis,fertilization,and embryonic development,which involve the regulation of telomere length,mitochondrial and spindle function,maintenance of genomic stability,and expression of anti-aging proteins.The association and mechanism of telomerase with the quality of aged oocytes are summarized in order to provide new ideas for improving female fertility.
Keywords：TelomeraseTelomere shorteningOocytesInfertilityfemaleEmbryonic development
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 57-60,78 )