The Relationship between Vaginal Microecology and Cervical Cancer in HIV-Infected Women
HU Ming-zhu
LIU Li-wen
HUANG Lei
Abstract：The number of women acquiring human immunodeficiency virus(HIV)infection through sexual transmission is increasing.The immunocompromisedstate resulting from HIV infection significantly elevates the risk of infections and tumorigenesis in women.Growing evidence indicates that women living with HIV(WLHIV)exhibit increased detection rates of various vaginal pathogens,including bacteria,fungi,Trichomonas,Mycoplasma,and human papillomavirus(HPV),while simultaneously showing decreased Lactobacillus prevalence.This dysbiosis predisposes WLHIV to genital infections and cervical cancer.Therefore,strategies aimed at enhancing immunity,improving the vaginal microenvironment,and actively managing cervical precancerous lesions can contribute to reducing the incidence of sexually transmitted infections and cervical cancer.This review summarizes the alterations in the vaginal microecology of WLHIV and their association with the development of cervical cancer.
Keywords：HIV infectionsVaginaMicroecologyPapillomaviridaeReproductive tract infectionsUterine cervical neoplasmsPrecancerous conditions
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 13-18 )