Regulatory Mechanism of Ovarian Granulosa Cell Apoptosis in Polycystic Ovary Syndrome with Progress in Traditional Chinese Medicine
LI Dong-nan
XIANG Rong
WANG Hai-yang
SUN Miao
Abstract：Polycystic ovary syndrome(PCOS)is an endocrine and metabolic disease that affects female reproductive health throughout her life from the onset of puberty to pre-and post-menopause.The study of PCOS is complicated due to the heterogeneity of clinical manifestations,biochemical characteristics and pathogenesis.The current study shows that the abnormal follicular development is closely related to the increased apoptosis of ovarian granulosa cells in PCOS patients,which changes the pathological state of abnormal apoptosis of granulosa cells and can affect the process of PCOS by intervening insulin resistance(IR),regulating ovarian hormone microenvironment,antagonizing the state of oxidative stress,regulating inflammatory factors and lipid metabolism.Traditional Chinese medicine has the advantages of synergistic multiple targets,multi-pathway intervention in ovarian granulosa cell apoptosis.This article tries to retrieve and summarize relevant literature from domestic and abroad,review the intervention of IR,hyperandrogenism,oxidative stress,chronic low-grade inflammation and lipid metabolism mechanism regulation of PCOS,in order to provide a theoretical basis for clinical prevention and treatment of PCOS.
Keywords：Polycystic ovary syndromeGranulosa cellsApoptosisTraditional Chinese drugsTherapy
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 692-697 )