Mechanism Study of MAPK Pathway in PCOS and Monomeric Treatment of Traditional Chinese Medicine
HU Die
REN Jia-jie
LIU Jia-ning
FENG Xiao-ling
Abstract：Polycystic ovary syndrome(PCOS)is a common and complex gynecological endocrine disorder that mainly affects women of childbearing age.Its main characteristics include ovulation disorders,insulin resistance and hyperandrogenemia.The mitogen-activated protein kinase(MAPK)signaling pathway plays an important role in the occurrence of PCOS.It has been confirmed that the three classic MAPK pathways-extracellular signal-regulated kinase(ERK),c-Jun N-terminal kinase(JNK),and p38 MAPK are closely related to the occurrence of PCOS.Once these pathways are abnormally activated,it will prompt the body to have a variety of adverse reactions and ultimately lead to PCOS.Specifically,it includes ovulation dysfunction,insulin resistance,elevated androgen levels,oxidative stress and inflammatory reactions.Studies have shown that a variety of traditional Chinese medicine monomers can regulate the activity and expression of MAPK signaling pathway-related proteins.These traditional Chinese medicine monomers include flavonoids,glycosides,terpenoids,alkaloids and polysaccharides.Through this modulation,they can effectively improve the pathophysiological process of PCOS patients,thus providing new ideas and methods for the treatment of PCOS.
Keywords：Polycystic ovary syndromeMitogen-activated protein kinasesTraditional Chinese medicine monomersInsulin resistanceHyperandrogenism
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 684-691 )