Advances in Uterine Leiomyosarcoma:Mapping Based on Genomics
CHEN Xing-yu
WEI Ya-jing
LIANG Yan-chun
Abstract：Uterine leiomyosarcoma(uLMS)is one of the most common uterine sarcomas with features such as chromosome instability,strong invasiveness and poor prognosis.The diagnosis of uLMS is mainly based on histopathology,with a lack of specificity in other auxiliary examination techniques.In recent years,with the maturation of high-throughput sequencing technology,genomics has witnessed rapid development in the research on the pathogenesis of uLMS,uncovering multiple gene-specific molecular alterations such as gene upregulation,downregulation,mutations,and gene fusions.This review will systematically introduce the latest progress of uLMS in genomics research.The goal is to construct a multi-angle and multi-faceted heterogenetic map of uLMS,and provide basis and direction for the accurate and early diagnosis of uLMS at the molecular level as well.
Keywords：Uterine neoplasmsLeiomyosarcomaHigh-throughput nucleotide sequencingGenomicsTumor biological behavior
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 641-647 )